Van de Ven Double Ends The Toffees' Run at Brand New Stadium
Micky van de Ven emerged as the first defender to score two goals in a English top-flight match for Spurs since Jan Vertonghen in spring 2013.
At a glance
Micky Van de Ven heads home two times in opening period
Everton's defender has goal ruled after VAR review
Pape Matar Sarr nets third in 89th minute
The defeat is Everton's first at their new ground
The Tottenham defender found the net on two occasions as Tottenham extended their unbeaten run in away games in the top division and handed the Toffees their initial loss at their new home.
The Toffees were unbeaten in their five previous fixtures at their recently opened stadium at Bramley-Moore Dock, having left Goodison Park behind after 133 years at the end of last season.
But Tottenham's leader the Dutchman struck twice from set-pieces in the opening 45 minutes to put their impressive record at jeopardy, and they were failed to turn it around before Pape Matar Sarr - set up by former Toffees attacker the Brazilian - headed home a final goal to put the game to bed.
Jake O'Brien believed he had equalized the tally five minutes after Van de Ven's opener, glancing a powerful header past Guglielmo Vicario from an Everton corner.
The Portuguese striker, meanwhile, missed a number of opportunities, while Vicario made a series of fine stops to guarantee the London club went five away games unbeaten in the Premier League.
But the VAR stepped in, instructing Craig Pawson to review the score on the pitchside monitor and the referee decided that Jack Grealish and Iliman Ndiaye were in offside positions and had impeded with the Spurs keeper.
This victory elevates the manager's team into third place in the division, a handful of points off north London rivals and leaders Arsenal.
Everton stay in 14th position and sit half a dozen points ahead of the drop zone.
Tottenham analysis: Van de Ven excels in role at each end of the field
Following a drab weekday display in the Champions League against the French side, where they managed a mere two shots on target, the manager chose the French striker up front instead of former Toffees player Richarlison.
The summer signing was unable to make much of an impact before being replaced for Richarlison after 60 minutes on the pitch, but it turns out he proved unnecessary in the final outcome.
Centre-back the Dutchman converted into an offensive threat to be reckoned with.
Spurs' first goal came from a cleverly executed set-piece play, with Rodrigo Bentancur directing the ball toward the face of goal for an free Van de Ven to head home.
And the captain - stepping up as captain in the Argentine's unavailability - notched his second in added time as he rose above the England keeper to head home.
Van de Ven was equally outstanding in defensive duties, combining effectively with his defensive colleague as the duo dealt excellently with the numerous deliveries thrown their way by Everton.
Everton analysis: Everton missing striker's instinct
Everton's new home had been a happy hunting ground, but it appears the novelty may have faded somewhat and fans flocked to the exits after Sarr's final goal for Tottenham.
The break in the team's winning streak at home will not be a massive concern for the manager, but their attacking woes are.
The forward and Thierno Barry - the Toffees' pair of recognised strikers - had scored just a single goal between them before Sunday's match.
And they were unable to contribute to that miserable tally on a wet and gloomy evening on in Liverpool.
Beto's form was summed up when he chose to overhead kick a golden opportunity from close range, even with having space and opportunity to reposition for a simpler attempt that would have tested the keeper.
The substitute, too, was unable to make an impact after replacing the starter in the 65th minute.
It wasn't for a lack of opportunity. Most of Everton's attacks came through the winger and the forward, who tirelessly delivered threatening crosses into the Spurs penalty area.
Upcoming fixtures for both teams?
The Toffees: The team head to Sunderland in the Premier League on early November at 8 PM.
Spurs: Spurs travel to Newcastle's ground on late October for their next round League Cup match against Newcastle.